12/17/2023 0 Comments Gswitch a10Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen. Adherent cell function in murine T-lymphocyte antigen recognition. Rosenwasser LJ, Dinarello CA, Rosenthal AS.Long-term maintenance of HLA-D restricted T cells specific for soluble antigens. Kurnick JT, Altevogt P, Lindblom J, Sjöberg O, Danneus A, Wigzell H.Induction of proliferation of human T cells and T-cell blasts by monocyte-derived factors and lectin. Presence of immunoglobulin M-secreting plasmacytoid cells in peripheral blood and failure of immunoglobulin M-immunoglobulin G switch in B-cell differentiation. Geha RS, Hyslop N, Alami S, Farah F, Schneeberger EE, Rosen FS.Macrophage T-cell interaction in man: handling of tetanus toxoid antigen by human monocytes. Alpert SD, Jonsen ME, Broff MD, Schneeberger E, Geha RS.The biochemistry, biology, and role of interleukin 2 in the induction of cytotoxic T cell and antibody-forming B cell responses. Farrar JJ, Benjamin WR, Hilfiker ML, Howard M, Farrar WL, Fuller-Farrar J.The role of interleukin 1 in human B cell activation: inhibition of B cell proliferation and the generation of immunoglobulin-secreting cells by an antibody against human leukocytic pyrogen. Lipsky PE, Thompson PA, Rosenwasser LJ, Dinarello CA.Role of interleukin 1 in antigen-specific T cell proliferation. Chu E, Rosenwasser LJ, Dinarello CA, Lareau M, Geha RS.Macrophage-dependent activation of antigen-specific T cells requires antigen and a soluble monokine. DeFreitas EC, Chesnut RW, Grey HM, Chiller JM.Accessory cell stimulation of T cell proliferation requires active antigen processing, Ia-restricted antigen presentation, and a separate nonspecific 2nd signal. Links to PubMed are also available for Selected References. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Full textįull text is available as a scanned copy of the original print version. These results indicate that the patient's T-cell deficiency was due to a defective T-cell response to IL-1 and suggest that IL-1 plays an important role in the in vivo immune response. T-cell blasts derived from a normal subject but not T-cell blasts derived from the patient absorbed out IL-1 activity from a preparation of purified human IL-1. IL-2 production by the patient's phytohemagglutin-stimulated PBMC was severely deficient but was corrected by the addition of phorbol 12-myristate 13-acetate, suggesting a defective response to IL-1. The abnormal phytohemagglutinin response of the patient's PBMC was corrected by the addition of exogenous IL-2. Monocyte function in this patient was normal as judged by the following criteria: normal expression of Ia antigens (77% +), normal IL-1 production, and normal capacity to present tetanus toxoid to a maternal T-cell line specific for tetanus toxoid antigen. Delayed hypersensitivity skin tests and in vitro response to tetanus toxoid remained absent despite repeated immunizations. However, the in vitro proliferative response of his peripheral blood mononuclear cells (PBMC) to phytohemagglutinin was depressed (40% of normal) and the response of his PBMC to antigens was absent. The patient had normal levels of serum immunoglobulins and a normal distribution of circulating T-cell subsets. A 10-year-old male with recurrent infections and failure to thrive was evaluated for possible defects in the production and response to IL-1 and IL-2. Optimal IL-2 production by T cells is dependent on the monokine interleukin 1 (IL-1). Normal proliferation of T cells in vitro requires production of and response to the lymphokine interleukin 2 (IL-2).
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